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All are serine esterases that harbor a common structural elementthe alpha/beta-hydrolase foldand a conserved catalytic diad or triad that is composed of the G X S X G pentapeptide motif as well as an active aspartate or glutamate (D/E)GG tripeptide and an active histidine (H)

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Ideal Candidate Profiles Adults with confirmed GH deficiency by stimulation testing Patients experiencing age-related GH decline Individuals with mild to moderate metabolic syndrome Contraindications and Precautions Active cancer or history of pituitary tumors Untreated thyroid disorders Pregnancy or breastfeeding Severe kidney or liver impairment Disclose all medical history and medications before starting sermorelin therapy